PHARMACOLOGICAL STUDY ON ACUTE TOXICITY OF MERCURIC CHLORIDE IN MICE

Maruyama Shichiro, Hachisu Mitsugu, Iwanaga Hiroaki, Ino Yoshitaka, Ogasawara Sadanori, Yamada Shigeo

doi:10.14930/jsma1939.37.449

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急性昇汞 (HgCl<SUB>2</SUB>) 中毒に対する2, 3解毒薬の効果
急性昇汞(HgCl2)中毒に対する2,3解毒薬の効果
キュウセイショウコウ HgCl2 チュウドクニタイスル 2 3 カイド

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Abstract

Antidotal effects of α-mercaptopropionyl glicine (MG) and 6, 8-dithioctanic acid (lipoic acid; LA) on mercuric chloride-intoxicated mice and histological examination were investigated. Results are as follows.<BR>After administration of mercuric chrolide in the mice were observed for 7 days. The LD₅₀was caluculated by the method of Litchfield-Wilcoxon. The LD₅₀in the mice was 7.7 mg/kg intravenously. Acute toxic symptoms were observed in mice, depressed of spontaneous movements, piloerection, mydriasis, salivation, tremor convulsion, no righting reflex, depressed respiration. Histological findings of kindney in the mercuric chloride treated mice were noticed degeneration of hyaline droplet, hyperemia of cortex and medulla, dystropic calcification in proximal convoluted tubule and Henle's loop.<BR>Antidotal effects of MG and LA on mercuic chloride intoxicated at doses of LD₅₀were noticed decrease of mortality when administrated of combination with mercuric chloride and MG or LA.

Journal

Journal of The Showa Medical Association

Journal of The Showa Medical Association 37 (5), 449-454, 1977

The Showa University Society

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