低セルロプラスミン血症ラットにおける鉄代謝―網内系機能との関連―

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  • IRON METABOLISM IN HYPOCERULOPLASMINEMIC RATS, WITH SPECIAL REFERENCE TO THE FUNCTION OF RETICULOENDOTHELIAL SYSTEM
  • テイ セルロプラスミン ケッショウ ラット ニ オケル テツ タイシャ モウナ

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The biological role of the ferrous to ferric alteration in iron metabolism has not been sufficiently elucidated. However, one of the principal points of iron metabolism is the ferroxidase reaction in which the oxidation of iron is catalyzed by ceruloplasmin.<BR>The effects of ceruloplasmin in iron kinetics were studied in hypoceruloplasminemic rats by copper deprivation. Consequently, markedly reduced plasma iron levels were found in copper deficient rats.<BR>Both copper dificient and control rats were given intravenously 1.0μCi/100 g of body weight59Fe chondroitic iron sulfate. In copper deficient rats, liver, spleen, kidney and bone marrow, radio-iron activities were higher than in control rats. Radio-iron incorporation into hepatic ferritin was also increased in copper deficient rats. The release of radio-iron from these organs to peripheral blood was impaired in deficient rats. However, the rates of clearance of carbon particles from blood, which indicated the granulopectic activities of the reticuloendothelial systems, were similar in two groups. In copper deficient rats, it was suggested that hypoferremia is the consequence of an inability to utilize storage iron.<BR>These findings support the hypothesis that ceruloplasmin, becasue of its ferroxidase activity, accelerates the release of iron from reticuloendothelial system tissues to plasma.

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