Alloalbuminemiaに関する研究

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  • 千住 紀
    昭和大学医学部大学院医学研究科内科系臨床病理学

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タイトル別名
  • STUDIES ON ALLOALBUMINEMIA
  • Alloalbuminemia ニカンスルケンキュウ

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Two divided peaks of albumin fraction, so-called double albumin, are sometimes observed in spite of the fact that albumin usually has been shown a big band on electrophoretic pattern of serum protein. There are two kinds of double albuminemia : one is acquired and the other is hereditary, the latter is called as“alloalbuminemia”.<BR>In this paper, the chemical and physicochemical properties of alloalbumin (albumin-N and albumin-S) obtained from the healthy man who had been found alloalbuminemia by health examination and its hereditary characteristics were reported.<BR>Albumin-N and albumin-S were observed with cellulose acetate agar, and disc electrophoresis. Albumin-S was more labile than albumin-N in the storage at 4°C, after stored for 2 months albumin-S migrated closely albumin-N, but not completely identical. No immunological differences between both albumins were observed. With Sephadex gel filtration and ultracentrifugation, both had almost the same molecular size.<BR>Compared with the ratio of amino acids content in both albumins, albumin-S contained lesser glutamic acid and more prolin and basic amino acids than albumin-N. I speculate that the composition of albumin-S is like as proalbumin.<BR>The type of hereditary trait of this alloalbuminemia had been certified normochromosomal co-dominant by the observation of 4 generations in this family.

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