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- Takiuchi Takeshi
- Department of Pharmacology, School of Medicine, Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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- Shimizu Noriyuki
- Department of Pharmacology, School of Medicine, Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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- Nishijima Taturo
- Department of Pharmacology, School of Medicine, Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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- Amemiya Hisao
- Department of Pharmacology, School of Medicine, Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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- Namatame Eiichi
- Department of Pharmacology, School of Medicine, Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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- Yamada Shigeo
- Department of Pharmacology, School of Medicine, Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
Bibliographic Information
- Other Title
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- 抗ヒスタミン剤の端板電位に及ぼす影響
- コウヒスタミンザイ ノ タンバン デンイ ニ オヨボス エイキョウ
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Description
Effects of several antihistaminics such as promethazine, triplennamine and pandryl-p, on the end-plate potential and action potential comparing with that of d-tubocurarine and decamethonium were studied electrophysiologically using sciatic-sartorius preparation of toads and phrenic-diaphragm preparation of rats by the Ozawa's insulation method. The following results were obtained :<BR>1) When Sciatic-sartorius preparation of toads were used, by the administration of the antihistaminics the action potential decreased gradually and finally disappeared completely and thereafter the end plate potential appeared markedly which were the same as the case of d-tubocurarine and decamethonium.<BR>2) When the phrenic-diaphragm preparation of rat was used, by the administration of d-tubocurarine almost the same effects were observed as the previous experiment, while by the administration of decamethonium, the latent period was prolonged remakably and the action potential did not disappeared which was followed to the end-plate potential.<BR>3) In case of promethazine and pandryl-p almost the same effects were observed as the case of decamethonium.
Journal
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- Journal of The Showa Medical Association
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Journal of The Showa Medical Association 30 (6), 350-357, 1970
The Showa University Society
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Details 詳細情報について
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- CRID
- 1390282679816580608
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- NII Article ID
- 130001820369
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- NII Book ID
- AN00117027
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- ISSN
- 21850976
- 00374342
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- NDL BIB ID
- 8251091
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed