ISOLATION OF MULTIDRUG-RESISTANT <i>Pseudomonas aeruginosa</i>, ESBL-PRODUCING <i>Escherichia coli</i>, ESBL-PRODUCING -<i>Klebsiella pneumoniae</i>, ESBL-PRODUCING -<i>Klebsiella oxytoca</i> AND MULTIDRUG-RESISTANT <i>Acinetobacter baumannii</i> IN SHOWA UNIVERSITY HOSPITAL(FISCAL YEAR 2006-2010)

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  • 昭和大学病院におけるMultidrug resistant <i>Pseudomonas aeruginosa</i>, ESBL産生<i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, <i>Klebsiella oxytoca</i>およびMultidrug resistant <i>Acinetobacter baumannii</i>の検出状況（2006～2010年度）
  • 昭和大学病院におけるMultidrug resistant Pseudomonas aeruginosa, ESBL産生Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytocaおよびMultidrug resistant Acinetobacter baumanniiの検出状況(2006~2010年度)
  • ショウワ ダイガク ビョウイン ニ オケル Multidrug resistant Pseudomonas aeruginosa, ESBL サンセイ Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca オヨビ Multidrug resistant Acinetobacter baumannii ノ ケンシュツ ジョウキョウ(2006~2010ネンド)

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We report the isolation of multidrug resistant Pseudomonas aeruginosa (MDRP), extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli, ESBL-producing Klebsiella pneumoniae, ESBL-producing Klebsiella oxytoca and multidrug-resistant Acinetobacter baumannii in Showa University Hospital (Fiscal Year 2006-2010). MDRP were identified as 1 to 5 strains monthly, corresponding to 0.5-6% of total P aeruginosa isolates. ESBL-producing E. coli were identified as 10-40 strains monthly, 10-20% of total E. coli isolates. ESBL-producing E. coli occupied most of the third generation cephalosporin-resistant E. coli. From 10-20% of total K. pneumoniae isolates showed resistance to the third generation cephalosporin. About half of the third generation cephalosporin-resistant K. pneumoniae, 2-4 strains monthly, were identified as ESBL producing. From 10-20% of total K. oxytoca isolates showed resistance to the third generation cephalosporin-resistant, 2-6 strains monthly. ESBL producing strain. The number of MDRP and ESBL producing strains and the ratio to total isolates did not fluctuate from FY2006 to 2010. Ten to twenty strains of A. baumannii were isolated monthly in FY2010. Strains resistant to three antibiotic groups; Carbapenems, Aminoglycosides and Fluoroquinolones, were detected in 6 specimens of 4 patients in FY2010. Among them, 2 strains from 1 patient were resistant to Imipenem, Amikacin and Ciprofloxacin, and were identified as a definitive MDRA. The remaining 4 strains from 3 patients were resistant to Meropenem, Gemtamicin, and Ciprofloxacin, and were sensitive to Imipenem and Amikacin. To prevent the spread of drug-resistant bacteria, appropriate reporting efforts are necessary. Further, a sensitive method to detect drug-resistant strains using gene analysis should be established.

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