抗ムンプスＩｇＭ抗体が持続陽性を示した急性感音難聴の１例

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  • Acute Sensorineural Hearing Loss Associated with Persistent Positivity of Antimumps IgM Antibody.

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Some patients with acute sensorineural hearing loss are anti-mumps IgM antibody positive on serological examination, although they do not have clinical symptoms of mumps. They account for 1-7% of patients with acute sensorineural hearing loss. It has been reported that anti-mumps IgM antibody becomes negative about 3 months, 6 months at longest, after mumps infection.<br>A patient had acute progressive hearing loss (The mean hearing threshold of 63.8dB) probably of inner ear origin. Hearing loss was refractory to medical therapy, and it was considered to be caused by latent mumps infection. The anti-mumps IgM autibody titer was 2.30 (positive) on the onset of disease, remained at a high level and 1.60 (positive) 15 months after therapy. An antigen absorption test and globulin fractionation with a sucrose density gradient centrifugation method showed that anti-mumps igM antibody in the patient's serum was mumps-specific. IgG avidity was found to be 7%.<br>A relationship between the onset of acute sensorineural hearing loss and persistent positivity of anti-mumps IgM antibody was suspected. Anti-mumps IgM antibody positive patients with acute sensorineural hearing loss may have persistent mumps infection as cause of hering loss.

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