Effect of Methylprednisolone upon Susceptibility to Acoustic Trauma.

DOI Open Access
  • Takahashi K.
    Department of Otolaryngology, University of Tsukuba
  • Kimura S.
    Department of Otolaryngology, University of Tsukuba
  • Wada T.
    Department of Otolaryngology, University of Tsukuba
  • Ase Y.
    Department of Otolaryngology, University of Tsukuba
  • Hara A.
    Department of Otolaryngology, University of Tsukuba
  • Kusakari J.
    Department of Otolaryngology, University of Tsukuba

Bibliographic Information

Other Title
  • メチルプレドニゾロンの強大音受傷性に与える影響

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Description

To investigate the effect of steroid upon acoustic trauma, 32 albino guinea pigs were given 12 or 40mg/kg methylprednisolone (mPSL) i.v. and exposed to 2kHz pure tone of 110 or 120 dBSPL for 10min. The threshold of the compound action potential (CAP) were examined before and every 30min after the exposure to intense sound. The CAP threshold shift by acoustic overstimulation in these mPSL pretreated animals was not significantly different from that in the control animals. However, some mPSL given animals exhibited significant recovery in the CAP threshold during the observation period of 3 hours, while the threshold shift was quite minimal in the control. These results indicate that mPSL dose not exert in a protective manner but has presumably some effects on the recovery from the damage induced by acoustic overstimulation.

Journal

  • AUDIOLOGY JAPAN

    AUDIOLOGY JAPAN 37 (4), 288-294, 1994

    Japan Audiological Society

Keywords

Details 詳細情報について

  • CRID
    1390282679816817920
  • NII Article ID
    130003862301
  • DOI
    10.4295/audiology.37.288
  • ISSN
    18837301
    03038106
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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