THE SHORT-TERM VARIATION OF THE RATIO OF EICOSAPENTAENOIC ACID TO ARACHIDONIC ACID IN PATIENTS WITH STABLE ANGINA PECTORIS

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  • OKABE Toshitaka
    Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital
  • YAMAMOTO Myong Hwa
    Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital
  • YAMASHITA Kennosuke
    Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital
  • EBARA Seitaro
    Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital
  • SAITO Shigeo
    Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital
  • HOSHIMOTO Koichi
    Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital
  • YAKUSHIJI Tadayuki
    Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital
  • ISOMURA Naoei
    Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital
  • ARAKI Hiroshi
    Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital
  • OBARA Chiaki
    Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital
  • OCHIAI Masahiko
    Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital

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Other Title
  • 安定狭心症患者におけるEPA/AA比の短期間での変動
  • アンテイ キョウシンショウ カンジャ ニ オケル EPA/AAヒ ノ タンキカン デ ノ ヘンドウ

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Abstract

Background: A low blood ratio of eicosapentaenoic acid to arachidonic acid (EPA/AA ratio) is a known risk factor for ischemic heart disease, however, little is known aboutthe short-term variation of the EPA/AA ratio. Objective: To investigate possible short-term variation of the EPA/AA ratio in patients with stable angina. Methods: The subjects were 38 patients who had stable angina and at least one lesion with 75% stenosis that required revascularization based on coronary angiography findings. The EPA/AA ratio was determined at 3 time points: 1) on admission to hospital for the first percutaneous coronary intervention (PCI)(on admission EPA/AA ratio), 2) during fasting before breakfast on the day of PCI (day of PCI EPA/AA ratio), and 3) during fasting on the day after PCI (day after PCI EPA/AA ratio). Results: The mean age of the subjects was 68.7 ± 9.7 years, 73.7% were men, 73.7% had hypertension, 71.1% had dyslipidemia, and 31.6% had diabetes mellitus. On admission the EPA/AA ratio, ratio on the day of PCI, and fasting ratio on the day after PCI were 0.47 ± 0.34, 0.46 ± 0.34, and 0.44 ± 0.34, respectively. The differences between these three values were significant (P < 0.01). Conclusion: The EPA/AA ratio may show short-term variation. Therefore, to obtain accurate evaluation of this ratio as a risk factor for ischemic heart disease, it may be important to standardize the timing of blood collection.

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