書誌事項
- タイトル別名
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- COMPARISON OF ENZYME IMMUNOASSAYS AND IMMUNOHISTOCHEMISTRY FOR THE DETECTION OF HORMONE RECEPTOR STATUS
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Purpose: The hormone receptor status of breast cancers is a predicting factor of their response to endocrine therapy. Thus, accurate assessment of a tumor's true hormone receptor status is vital to optimal treatment.<br>Patients: The estrogen receptor (ER) status of 316 breast cancers was examined using enzyme immunoassays (EIA) and immunohistochemistry (IHC).<br>Methods: The ER status of the tumors was investigated using EIA and IHC, and the concordance rates and problems with these techniques were compared.<br>Results and Conclusion: The EIA results showed that 43% of the tumors were positive for ER, while the IHC results showed that 66% of the tumors were positive. Therefore, the level of agreement with the EIA results was 75%. Tumors with low cellularity, scirrhous carcinomas and mucinous carcinomas may lead to unreliable EIA results. Furthermore, normal ductal epithelium cells that are positive for ER may also affect the EIA results. The criteria for IHC studies must be defined. However, when a negative ER result is obtained by EIA in metastatic breast cancers, the ER status should be confirmed using paraffin-fixed tissue sections and IHC. Endocrine therapy may be effective for the treatment of ER-positive tumors.
収録刊行物
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- 日本臨床外科学会雑誌
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日本臨床外科学会雑誌 65 (5), 1161-1166, 2004
日本臨床外科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679820738176
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- NII論文ID
- 130003604042
- 10013165251
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- NII書誌ID
- AA11189709
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- ISSN
- 18825133
- 13452843
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可