腹膜播種をきたした原発巣不明の肝細胞癌の1例

書誌事項

タイトル別名
  • A case report of peritoneal dissemination of hepatocellular carcinoma with unknown primary lesion.
公開日
2000
DOI
  • 10.3919/jjsa.61.3314
公開者
日本臨床外科学会

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説明

We report a case of peritoneal dissemination of hepatocellular carcinoma with unknown primary lesion in the liver. A 56-year-old man was admitted to the hospital for close examination of abdominal distension with bloody ascites. Ultrasonography, CT scan and angiography revealed only a hemangioma 2cm in size in the liver but no other space-occupying lesion in the liver. Laboratory examination showed only an elevation in serum alpha-fetoprotein (AFP; 870ng/ml). Liver function was within normal ranges. The patient had been exposed to asbestos for 30 years, so that malignant peritoneal mesothelioma was suspected. On July 22, 1997, an exploratory laparotomy was performed, which revealed about 4, 000ml of bloody ascites and multiple nodular hemorrhagic tumors approximately 1.0cm in size disseminated on the peritoneum and mesentery. Histopathologically the tumors resected from the peritoneum were diagnosed as hepatocellular carcinoma. Although intraperitoneal infusion of CDDP 100mg reduced ascites, patient's general condition gradually deteriorated. The patient succumbed to peritonitis carcinomatosa on December 11, 1997. An autopsy revealed no primary tumor lesion in the liver nor in any other organs. This case might have developed ectopic hepatocellular carcinoma in the abdominal cavity.

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