胃癌骨転移9症例の臨床病理学的検討

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  • CLINICOPATHOLOGICAL EVALUATION OF BONE METASTASIS OF GASTRIC CANCER IN 9 CASES

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We evaluated 9 patients with bone metastasis and 81 patients with other metastases from gastric cancer from a total of 587 patients with gastric cancer over the past 16 years. We evaluated both groups. Tumor size was significantly smaller and the rate of localized type was significantly larger in patients with bone metastasis than the other metastases. There were more patients with signet ring cell carcinoma. The depth of cancer invasion was high in both groups. More than 50% of patients with bone metastasis had lumbago. Localization of bone metastasis was vertebra in 44% and was diffuse in 44%. Serum alkaline phosphatase (ALP) levels were elevated even in the asymptomatic period and were more sensitive than LDH and carcinoembryonic antigen (CEA) in patients with bone metastasis.<br> Bone scintigraphy was useful for the diagnosis of bone metastasis. When ALP is elevated in asymptomatic patients with advanced gastric cancer, we should perform bone scintigraphy to facilitate earlier detection of bone metastasis.

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