SIGNIFICANCE OF SERUM KL-6 AS A TUMOR MARKER IN BREAST CANCER PATIENTS

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  • DOI Takako
    Department of Surgery, National Hospital Organization Yokohama Medical Center
  • TANABE Mikiko
    Department of Surgery, National Hospital Organization Yokohama Medical Center

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  • 乳癌患者血清中ＫＬ‐６の腫瘍マーカーとしての意義の検討

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KL-6, a sialoglycoprotein antigen that is expressed in cells such as type II alveolar epithelial cells, tends to be elevated in the serum of patients with interstitial pneumonia and has also been reported to be elevated in patients with malignant tumors. In the present study, we investigated the significance of KL-6 as a tumor marker in breast cancer by analyzing relationships between KL-6 levels and metastasis or relapse of breast cancer, tumor site, treatment effects, and other tumor markers. A total of 202 patients with breast cancer (158 cases of non-relapsing cancer, 44 cases of progressive or relapsing cancer) were investigated using electrochemiluminescence immunoassay. The optimal cutoff value for KL-6 as a marker of relapse was 290.5 U/ml. KL-6 was significantly higher in the progressive or relapsing group compared to the non-relapsing group, and had a sensitivity of 75%, specificity of 79.1%, diagnostic efficiency of 78.2%, positive predictive value of 50%, and a negative predictive value of 91.2%. Increases in KL-6 levels during relapse were significantly related to other markers. As an indicator of treatment effects, KL-6 significantly decreased in the improvement group and increased in the exacerbation group. KL-6 was thus considered useful for diagnosing metastatic or relapsing breast cancer as well as determining treatment effects.

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