Effect of Anastrozole on Bone Mineral Density after Completion of 5-year Adjuvant Treatment for Japanese Postmenopausal Women with Breast Cancer

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  • MATSUMOTO Takashi
    Department of Surgery, Mutual Aid Association of Public School Teachers Kinki Central Hospital

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  • アナストロゾールを5年間投与した乳癌患者の骨密度変化
  • 臨床経験 アナストロゾールを5年間投与した乳癌患者の骨密度変化
  • リンショウ ケイケン アナストロゾール オ 5ネンカン トウヨ シタ ニュウガン カンジャ ノ コツミツド ヘンカ

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Abstract

Treatment of postmenopausal women with breast cancer using aromatase inhibitors (AIs) is widely accepted as adjuvant therapy, but the negative effects of AIs on bone mineral density (BMD) are recognized. We evaluated changes in BMD of patients receiving anastrozole (ANA) as adjuvant therapy for 5 years. The study included 37 patients divided into the following four treatment groups : N-group (n=8), given ANA only ; V-group (n=5), ANA with vitamin D (Vit D) ; VB-group (n=10), ANA with Vit D first changed to bisphosphonates (Bis) ; and the B-group (n=14), ANA with Bis. Forearm BMD was assessed at baseline and then every year for 5 years in total. The percentage changes in BMD from baseline to 5 years were as follows : N-group, -11.7% ; V-group, -14.1% ; VB-group, -6.5% ; and B-group, +1.6%.<BR>While the BMD of V-group decreased most among the four groups, in response to changing Vit D to Bis, the degree of decrease was improved in the VB-group and it was possible to maintain BMD with addition of Bis from the start of adjuvant ANA in B-group. Our results suggest that BMD decline can be prevented by using Bis in Japanese postmenopausal women with hormone receptor-positive breast cancer scheduled to receive ANA.

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