A Case of Duodenal, Somatostatin-producing Neuroendocrine Tumor

OKUDE Teruo, KITAMURA Hirotaka, OTA Naohiro, INAKI Noriyuki, KUROKAWA Masaru, BANDO Hiroyuki, KURUMAYA Hiroshi

doi:10.3919/jjsa.77.1434

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十二指腸ソマトスタチン産生神経内分泌腫瘍の1例
症例十二指腸ソマトスタチン産生神経内分泌腫瘍の1例
ショウレイジュウニシチョウソマトスタチンサンセイシンケイナイブンピシュヨウノ 1レイ

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Abstract

A 51-year-old male patient was found to have a 20-mm submucosal tumor at the descending part of the duodenum on upper gastrointestinal endoscopy, as part of a general health examination. We diagnosed this as a somatostatin-producing, neuroendocrine tumor (NET). Contrast-enhanced abdominal computed tomography confirmed early-enhanced wall thickening at the descending part of the duodenum and a 25-mm area of lymphadenopathy near the horizontal part of the duodenum. We performed a subtotal stomach-preserving pancreaticoduodenectomy. Histopathological diagnosis primarily localized the tumor to the submucosa, with partial infiltration of the subserosa. We also found island-shaped and tubular growth of cells with oval-shaped nuclei, and somatostatin was positive by immunostaining. There was 1 mitotic figure/10 HPF, and the Ki-67 labeling index was 1.42% ; thus, we diagnosed a G1 somatostatin-producing NET. Metastasis was observed in #13 and #14d lymph nodes in accordance with General Rules for the Study of Biliary Tract Cancer (6th Edition). Duodenal somatostatin-producing NET is relatively rare. Thus, we report this case with a literature review.

Journal

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 77 (6), 1434-1439, 2016

Japan Surgical Association

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