A Patient with Neuroendocrine Cell-type Colon Cancer who Benefited from Multidisciplinary Therapy

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  • 集学的治療が奏効した大腸原発内分泌細胞癌の1例
  • 症例 集学的治療が奏効した大腸原発内分泌細胞癌の1例
  • ショウレイ シュウガクテキ チリョウ ガ ソウコウ シタ ダイチョウ ゲンパツ ナイブンピ サイボウガン ノ 1レイ

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Abstract

A 59-year-old woman with right lower abdominal pain and fever was admitted to another hospital and diagnosed as having colitis. However, the pain gradually worsened, and follow-up CT on day 10 after the symptom onset revealed findings suggestive of advanced ascending colon cancer. She was admitted to our hospital and diagnosed as having neuroendocrine cell colon cancer, Stage IIIb, based on the colonoscopy, histology and CT findings. Neoadjuvant chemotherapy was initiated with CDDP+CPT-11, a regimen commonly used for the treatment of small cell lung cancer, and partial response was obtained. The neoadjuvant chemotherapy was followed by laparoscopic-assisted right hemicolectomy ; the same regimen was then repeated after surgery, in combination with 5 courses of XELOX, as adjuvant chemotherapy. Until now, 18 months since the operation, there has been no evidence of recurrence. Neuroendocrine- type colon cancer is very rare and its prognosis is quite poor. Herein, we report a patient with neuroendocrine cell-type colon cancer, for which multidisciplinary therapies, including neoadjuvant chemotherapy, was effective. Especially, it is suggested that neoadjuvant chemotherapy is effective, because of the remarkable outcomes in this case and also in a previously reported cases.

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