A case of breast cancer and pheochromocytoma associated with neurofibromatosis type 1

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  • 乳癌と副腎褐色細胞腫を合併した神経線維腫症1型の1例

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Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder. Individuals with NF1 are acknowledged to be at increased risk of malignancy, but the complication of epithelial tumors is relatively uncommon. Here, we report a rare case of breast cancer and pheochromocytoma associated with NF1. A 48-year-old woman was brought to the hospital because of left breast pain. She had a lump in the lower outer quadrant of the left breast, and multiple café au lait spots and soft tumors in the skin of the whole body. Aspiration cytology revealed breast cancer. Preoperative abdominal computed tomography revealed a left adrenal tumor. Endocrinous laboratory data and a 131-I-MIBG scintigram offered a diagnosis of left adrenal pheochromocytoma. The patient was diagnosed as having left breast cancer and left adrenal pheochromocytoma with NF1. We performed a laparoscopic left adrenalectomy for pheochromocytoma, followed by a left radical mastectomy for breast cancer. Here, we present the case report and a review of the literature.

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