Factors Associated with Febrile Neutropenia Caused by Combined Chemotherapy with Docetaxel, Cisplatin and 5-FU for Esophageal Cancer

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  • NAKAHARA Yujiro
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
  • YAMASAKI Makoto
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
  • MAKINO Tomoki
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
  • MIYAZAKI Yasuhiro
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
  • TAKAHASHI Tsuyoshi
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
  • KUROKAWA Yukinori
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
  • NAKAJIMA Kiyokazu
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
  • TAKIGUCHI Shuji
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
  • MORI Masaki
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
  • DOKI Yuichiro
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University

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Other Title
  • 食道癌DCF療法における発熱性好中球減少症に関連する因子の検討
  • ショクドウ ガン DCF リョウホウ ニ オケル ハツネツセイ コウチュウキュウ ゲンショウショウ ニ カンレン スル インシ ノ ケントウ

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Abstract

Background : Combined chemotherapy with docetaxel, cisplatin and 5-FU (DCF therapy) for esophageal cancer is expected as a treatment alternative to the combination of 5-FU and cisplation (FP therapy). On the other hand, it has been reported that DCF therapy causes myelosuppression and febrile neutropenia (FN) in a high frequency. Methods : A total of 108 patients who received DCF therapy in our hospital from 2010 to 2012 were eligible for this study. We studied the frequencies of hematotoxicity and FN, and factors associated with FN. Results : The patients' characteristics included a median age of 67 years ; the male/female ratio of 100/8 ; and UICC Stage I/II/III/IV of 7/9/53/39. Grade 4 neutropenia and FN were found in 54.6% and 37.0% of all patients, respectively. Advanced age and dysphagia were independent factors associated with FN. Conclusions : DCF therapy for esophageal cancer frequently caused neutropenia and FN. Factors associated with FN were revealed. This study suggested the possibility of individualization in chemotherapy for esophageal cancer.

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