A Case of Radiation-induced Angiosarcoma after Conservative Treatment for Breast Cancer

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  • OGATA Takashi
    Department of Breast Surgery, Yamagata Prefectural Central Hospital
  • KUDO Shun
    Department of Breast Surgery, Yamagata Prefectural Central Hospital
  • MAKINO Takatoshi
    Department of Breast Surgery, Yamagata Prefectural Central Hospital
  • HASUNUMA Ayako
    Department of Breast Surgery, Yamagata Prefectural Central Hospital

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Other Title
  • 乳房温存療法後に発生した放射線誘発血管肉腫の1例
  • 症例 乳房温存療法後に発生した放射線誘発血管肉腫の1例
  • ショウレイ チブサ オンゾン リョウホウ ゴ ニ ハッセイ シタ ホウシャセン ユウハツ ケッカン ニクシュ ノ 1レイ

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Abstract

A case of radiation-induced angiosarcoma that occurred 5 years and 8 months after initial breast conservative surgery is described.<BR>The patient was a 32-year-old woman who had undergone breast conservative surgery for left breast cancer when she was 25 years old, followed by CMF therapy and radiation therapy with a total dose of 50 Gy. Five years and 3 months after the initial operation, an episode of blunt trauma to the residual left breast caused internal bleeding with purpura. Since the hematoma continued for 5 months, and a tumor-like nodule developed, a needle biopsy was performed, and a radiation-induced angiosarcoma was diagnosed. She underwent a mastectomy with wide skin excision and adjuvant systemic chemotherapy with paclitaxel. However, multiple liver and bone metastases and local recurrence occurred 1 year after the second operation. She deteriorated rapidly and died 4 months after the recurrence.<BR>Radiation therapy is commonly performed after breast conservative surgery. Radiation-induced angiosarcoma is very rare, and its prognosis is extremely poor. We must keep this disease in mind as a harmful complication of radiation therapy and should strive for its early detection and treatment.

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