A Case of Adenoendocrine Cell Carcinoma of the Gallbladder

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  • 胆嚢原発腺内分泌細胞癌の1例
  • 症例 胆嚢原発腺内分泌細胞癌の1例
  • ショウレイ タンノウ ゲンパツセン ナイブンピ サイボウガン ノ 1レイ

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Abstract

Adenoendocrine cell carcinoma of the gallbladder is rare with a dismal prognosis. A 77-year-old man was found to have an elevated lesion of the gallbladder following abdominal ultrasonography. CT and MRI revealed a 3-cm diameter tumor at the body of the gallbladder that was diagnosed as gallbladder carcinoma. Extended cholecystectomy was performed. Neither liver metastasis nor peritoneal dissemination was seen. Microscopically, the tumor consisted mainly of small atypical cells with a high nuclear/cytoplasmic ratio forming solid cellular nests, with well-differentiated adenocarcinoma replacing the mucosa. Immunohistochemical studies of tumor cells were positive for chromogranin A staining. The definitive pathological diagnosis was adenoendocrine cell carcinoma. Postoperatively, chemotherapy with CDDP and irinotecan was administered. He has been disease-free for 18 months since resection.

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