The Clinical Efficacy of Calcium Polycarbophil for Fecal Incontinence

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  • 便失禁に対するポリカルボフィルカルシウムの効果

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PURPOSE: Calcium polycarbophil (CP) is a synthetic, high molecular weight polymer with marked water retention and gel-forming capacities. The former property reduces constipation, whereas the gelling property ameliorates diarrhea. The aim of the present study was to determine the effect of CP for fecal incontinence (FI).<br> METHODS: A total of 72 FI patients (34 passive type, 25 mix type, 8 urge type) with a median age of 74 yr were enrolled. The causes of FI were: in 18 obstetric injury, 12 anal surgical injury, 6 idiopathic, 6 diabetes, etc. Before administration of CP, Wexner's score and anorectal manometry were measured. Patients received polycarbophil tablets at a dosage of 3g/day (six 0.5-g tablets). After oral administration of CP for over 4 weeks, Wexner's score and anorectal manometry were again measured.<br> RESULTS: Wexner's score was 11 before and 5 after administration (P<0.05). In contrast, there was no significant change in mean resting pressure with administration of CP. Seven patients had new or worsening symptoms of constipation after the administration of CP.<br> CONCLUSION: Although the etiology of FI is multifactorial, CP is useful in improving Wexner's score in patients with various types and causes of FI. CP seems promising as an anti-FI agent.<br>

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