Relation between the Half-life of Serum CEA during First-line Chemotherapy and the Overall Survival in Patients with Metastatic Colorectal Carcinoma

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  • 進行再発大腸癌に対する初回化学療法時のCEA値推移と生存期間の関連
  • 臨床経験 進行再発大腸癌に対する初回化学療法時のCEA値推移と生存期間の関連
  • リンショウ ケイケン シンコウ サイハツ ダイチョウガン ニ タイスル ショカイ カガク リョウホウジ ノ CEAチ スイイ ト セイゾン キカン ノ カンレン

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In order to analyze whether changes of the serum CEA values during first-line chemotherapy for metastatic colorectal carcinoma can predict the overall survival, we enrolled 40 patients with elevated serum CEA levels who were receiving first-line chemotherapy with an oxaliplatin-based regimen. First, patients in whom the serum CEA values continued to increase even after the start of chemotherapy were separated into one group. Then, the remaining patients were divided into two groups according to the half-life of serum CEA during first-line chemotherapy. We analyzed the overall survival and percentage of patients who could receive 3rd and further-line chemotherapy in the patient groups. Significant differences in the overall survival and percentages of patients who could receive 3rd or further-line chemotherapy were observed among the groups classified on the basis of changes in the serum CEA values during first-line chemotherapy. The CEA value per se had no relationship to the overall survival. These results suggest that the degree of change of the serum CEA levels during first-line chemotherapy can predict the overall survival in patients with advanced colorectal carcinoma.

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