Pouchitis after Restorative Proctocolectomy for Ulcerative Colitis

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Pouchitis, the most common long-term complication, is a nonspecific inflammation in the ileal pouch after restorative proctocolectomy for ulcerative colitis. The etiology and pathogenesis of pouchitis are still not well defined. Pouchitis is characterized by increased bowel movement, nocturnal soiling, fecal urgency, and abdominal cramping. Endoscopic examination is necessary for diagnosis and differential diagnosis of pouchitis. Although administration of antimicrobial agents rapidly improves symptoms of pouchitis in most patients, long-term administration may be necessary for endoscopic remission. Chronic refractory pouchitis impairs the quality of life of patients with ulcerative colitis who, as a result of restorative proctocolectomy, have been taken off their previous medication. The establishment of strategies to prevent pouchitis and proper management of chronic refractory pouchitis is a challenge to be addressed.<br>

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