Validation of Patients with Stage III Colon Cancer According to the TNM, 7th Edition

Watanabe Akira, Saitou Shuji, Hashimoto Yosuke, Kagawa Hiroyasu, Bekku Emima, Tomioka Hiroyuki, Shiomi Akio, Kinugasa Yusuke

doi:10.3862/jcoloproctology.64.6

Purpose: This study assessed the validation of patients with Stage III colon cancer according to the TNM, 7th edition (TNM7).<br> Patients and Methods: Patients with Stage III colon cancer who underwent curative surgery were investigated. We compared the relapse-free survival of these patients according to TNM7, the TNM 6th edition (TNM6) and Japanese General Rules (JGR7). We verified the relapse-free survival of these patients which we divided into subgroups according to the combination of T factor and N factor on TNM7.<br> Results: We reviewed 217 patients. The rates of 3-year relapse-free survival (3y-RFS) of the patients on TNM7 Stage IIIA, Stage IIIB and Stage IIIC were 95%, 82% and 74%. There was a significant difference in relapse-free survival of these patients in TNM7 (p = 0.0468), but no significant differences in TNM6 or JGR7. The main reason for the clear stratification in TNM7 was the up-staging of the patients with T4bN1 tumors (3y-RFS = 50%) from stage IIIB in TNM6 or JPG7 to Stage IIIC in TNM7.<br> Conclusion: The prognosis of patients with Stage III colon cancer on TNM7 was stratified, and was shown to be valid.<br>

Validation of Patients with Stage III Colon Cancer According to the TNM, 7th Edition

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