Effect of Nitroglycerin Ointment on Preoperative Maximum Anal Canal Resting Pressure in Patients With Hemorrhoids.

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  • 内痔核患者におけるニトログリセリン軟膏の最大こう門静止圧に対する影響について

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The effect of nitroglycerin ointment on preoperative maximum anal canal resting pressure (PMARP) was evaluated. Patients and Methods : This study included 90 patients with internal hemorrhoids, who underwent hemorrhoidectomy after receiving 0.5% nitroglycerin ointment, between December 2000 and April 2001. During the preoperative period, PMARP was measured before and after the administration of 0.5% nitroglycerin ointment. The 90 patients were divided into two groups (the higher group comprised 49 patients with a PMARP of 100mmlg or higher ; the lower group included 41 patients with a PMARP of lower than 100 mmHg). Results : 1) The PMARP prior to receiving 0.5 % nitroglycerin ointment was 110.2±52.2mmHg, which was significantly lower than the PMARP after receiving 0.5% nitroglycerin ointment (90.7±41.lmmHg) (p<0.0001).2) In the higher group, the frequency of cases whose PMARP dropped after receiving 0.5 % nitroglycerin ointment was significantly higher than in the lower group. 3) The percentage of PMARP after administration of 0.5 % nitroglycerin ointment in the higher group (75.2±20.8%) was significantly lower than in the lower group (85.7±17.2 %). Conclusion : In patients with internal hemorroids, nitroglycerin ointment was effective in decreasing PMARP, and particularly effective for higher group, and will lead to alleviation of postoperative anal pain for patients with hemorroidectomy.

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