A Case of Rectal Neuroendocrine Carcinoma Metastatic to the Brain

DOI Web Site 6 Citations 22 References
  • Morimoto Y.
    Department of Surgery, Kurashiki Riverside Hospital Department of General and Gastrointestinal Surgery, Kurashiki Central Hospital
  • Ookura M.
    Department of Surgery, Kurashiki Riverside Hospital
  • Iwagaki H.
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine and Dentistry
  • Kawamoto K.
    Department of General and Gastrointestinal Surgery, Kurashiki Central Hospital
  • Yoshida Y.
    Department of General and Gastrointestinal Surgery, Kurashiki Central Hospital
  • Itou T.
    Department of General and Gastrointestinal Surgery, Kurashiki Central Hospital

Bibliographic Information

Other Title
  • 脳転移をきたした直腸内分泌細胞癌の１例

Search this article

Abstract

A 53-year-old man was admitted because of constipation and was diagnosed by endoscopy and a biopsy as having poorly differentiated adenocarcinoma of the rectum. A low-anterior resection was performed. Pathological examination of the rectal tumor showed INFb ; ss ; ly2 ; v0 ; and n1 (+), stage IIIa ; and it was diagnosed as a malignant carcinoid. Twenty-nine months after the first operation, the tumor recurred, and a second resection operation was performed. A histological examination showed a highly increased mitotic rate and a high proliferation index (68%, Ki-67 positive cells). It was considered that the histologic appearance of the primary rectum and the metastatic tumor suggested neuroendocrine carcinoma, and the working diagnosis was histologically reinterpreted. After the second operation, the patient received CDDP and UFT chemotherapy. Seventeen months after the second operation, the tumor recurred in the pelvis. A third resection operation was performed, but five months after this operation, the tumor progressed, spread to the lymph nodes and brain, and the patient died. Neuroendocrine tumors are heterogeneous and potentially aggressive and can be distinguished from other tumors because their growth and cytologic features are typical. A case of brain metastasis from neuroendocrine carcinoma is rare. We discuss neuroendocrine carcinoma and review the literature.

Journal

Citations (6)*help

See more

References(22)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top