A family of congenital antithrombin III deficiency

DOI Open Access
  • KATOH Hidenori
    Department of Surgery 1, University of Occupational and Environmental Health
  • NISHIYAMA Mariko
    Department of Surgery 1, University of Occupational and Environmental Health
  • TAKEDA Shigeaki
    Department of Surgery 1, University of Occupational and Environmental Health
  • TAKAKI Akira
    Department of Surgery 1, University of Occupational and Environmental Health
  • OHSATO Keiichi
    Department of Surgery 1, University of Occupational and Environmental Health

Bibliographic Information

Other Title
  • 先天性アンチトロンビンＩＩＩ欠乏症の１家系

Description

A family of inherited antithrombin III (AT III) deficiency was reported. Propositus was a 42-year-old man with 10-year history of deep vein thrombosis and cerebral thromboembolism.<br>AT III was assayed for his family members in three consecutive generations by single radial immunodiffusion, electroimmunoassay by Laurell, progressive antithrombin activity by thrombin clotting time and chromogenic assay using S-2238. A significant decrease of plasma AT III levels with low activity was found in 8 (47%) out of 17 members investigated. Five (63%) of them had recurrent episodes of deep vein thrombosis of extremities and/or cerebral thromboembolism, mesenterial thrombosis and pulmonary embolism. In two dimensional crossed immunoelectrophoresis, mobility of their AT III in the heparinized agarose gel was identical with that of normal control. Thus, the family is classified as type I by Nagy or type Ia by Sas.

Journal

  • Blood & Vessel

    Blood & Vessel 14 (1), 83-85, 1983

    The Japanese Society on Thrombosis and Hemostasis

Keywords

Details 詳細情報について

  • CRID
    1390282679834257920
  • NII Article ID
    130004092490
  • DOI
    10.2491/jjsth1970.14.83
  • ISSN
    18842372
    03869717
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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