A case of Bufferin induced acute interstitial nephritis. Adding to analysis of immune cells, cytokine.
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- OKADA MITSURU
- Department of Pediatrics, Kinki University School of Medicine
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- YOSHIOKA KAZUO
- Department of Pediatrics, Kinki University School of Medicine
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- ISOKAWA SADANORI
- Department of Pediatrics, Kinki University School of Medicine
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- TAKEMURA TSUKASA
- Department of Pediatrics, Kinki University School of Medicine
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- KINOSHITA TOMOHIRO
- Department of Pediatrics, Kinki University School of Medicine
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- MAKI SUNAO
- Department of Pediatrics, Kinki University School of Medicine
Bibliographic Information
- Other Title
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- バファリンによると考えられた急性間質性腎炎の１例 免疫担当細胞，サイトカインの分析を加えて
- —Adding to analysis of immune cells, cytokine—
- ―免疫担当細胞,サイトカインの分析を加えて―
Abstract
This paper describes a case report of acute interstitial nephritis associated with Bufferin(R). A 15-year-old girl were referred to our hospital due to fever and renal dysfunction. Laboratory findings showed elevation of serum BUN and creatinine, and increased urinary β2-MG excreation. Light microscopic findings of her renal biopsy specimen revealed edema and numerous inflammatory cells in the interstitium, and minor alterations in glomeruli. The interstitial infiltrates consisted mainly of T cells and also monocytes/macrophages. Interstitial cells were labelled with antibodies to interleukin (IL)-1 and tumor necrose factor (TNF). Bufferin(R) was positive by lymphocyte stimulation test . Thus, we considered that this drug was causative in this case. This observation suggests the participation of cell -mediated immune injury in drug induced acute interstitial nephritis .
Journal
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- The Japanese Journal of Nephrology
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The Japanese Journal of Nephrology 34 (11), 1195-1199, 1992
Japanese Society of Nephrology