内毒素血症と血液凝固系 ＩＩ 骨髄，ひ細胞由来のａｎｔｉｃｏａｇｕｌａｎｔ活性
書誌事項
- タイトル別名
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- Endotoxemia and blood coagulation
- 2. 骨髄, 脾細胞由来の anticoagulant 活性
抄録
1. Procoagulant activity (P-activity) in the intact cells of bone marrow or spleen cells was higher than that in sonic lysate of these cells.<br>2. Sonic lysate of bone marrow or spleen cells had the anticoagulant activity (A-activity), which was stable against heating at 70°C for 30-60min.<br>3. A-activity was mainly found in the 40, 000xg supernatant of sonic lysate of the spleen cells.<br>4. With heat-treated 40, 000xg supernatant prepared from post-LPS-cells or normal-cells, A-activity was also detected in the unactivated partial thromboplastin time (PTT), activated partial thromboplastin time (APTT), prothrombin time (PT) and the thrombin-fibrinogen clotting time (TT).<br>5. A-activity (prolongation of PTT or TT) of bone marrow or spleen cells was also enhanced by endotoxin injection compared to saline injection.<br>6. With acid soluble protein (ASP, cationic protein) from bone marrow or spleen cells, A-activity was also detected in the PTT, APTT, and PT, however, was not in the TT.<br>7. ASP was also stable against heating at 80°C for 30min.<br>8. In ASP, endotoxin-detoxifying activity was observed.<br>ASP appears to exist in cytoplasma and to inhibit clotting by blocking the activation of factor X or the formation of plasma thromboplastin. These findings also suggest that the enhancements of P-activity and A-activity of bone marrow or spleen cells in endotoxemia would also regulate the manifestation of DIC.
収録刊行物
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- 血液と脈管
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血液と脈管 13 (2), 237-240, 1982
一般社団法人 日本血栓止血学会
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詳細情報 詳細情報について
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- CRID
- 1390282679835113344
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- NII論文ID
- 130004260752
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- ISSN
- 18842372
- 03869717
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可