モルモットの自己免疫性尿細管質性じん炎に対する細胞性免疫の関与

書誌事項

タイトル別名
  • Autoimmune Cell-Mediated Tubulo-interstitial Nephritis Induced in Guinea Pigs by Heterologous Renal Tubular Basement Membrane. (TBM)

抄録

Hartley female guinea pigs, weighing 200g to 250g or 500g, were injected with rat kidney homogenate, the tubular basement membrane (TBM), the Fx1, the liver homogenates and saline in complete Freund's adjuvant and were sacrificed at intervals ranging from 4 to 28 days.No renal lesions were observed in the liver-, Fx1- and saline-injected animals. In guinea pigs weighing 200g to 250g injected with kidney homogenate or TBM, tubulointerstitial nephritis was induced at 14 to 21 days. The lesions were characterized by mononuclear cell infiltrates and tubular cell damage which were observed by light and electron microscopy. However, no immunoglobulin G or C3 deposits along TBM or in the other tissue components were detected.In contrast, in guinea pigs weighing 500g injected with kidney homogenate or TBM, the lesions were characterized by deposition of IgG and C3 along TBM at 14 days, there after tubulo-interstitiall nephritis were developed.Transfer of lymph node cells from kidney-or TBM-injected donor (200g-250g) to irradiated normall recipients resulted in focal interstitial nephritis. However, transfer of irradiated or sonicated lymphh node cells produced no renal lesions. The findings obtained only when young female guinea pigs are used are interpreted as indicating that the tubulo-interstitial lesions results from cell-mediated reactivity against T BM-specific antigens.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390282679835230080
  • NII論文ID
    130004168826
  • DOI
    10.14842/jpnjnephrol1959.24.609
  • ISSN
    18840728
    03852385
  • PubMed
    7176175
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ