The Efficacy of Kanamycin Plus Metronidazole Administration as an OABP Against Incisional Surgical Site Infection in Colorectal Cancer Surgery

Ichimanda Michihiro, Etoh Tsuyoshi, Nakajima Kentaro, Hiratsuka Takahiro, Akagi Tomonori, Shibata Tomotaka, Ueda Yoshitake, Shiroshita Hidefumi, Inomata Masafumi

doi:10.3862/jcoloproctology.70.214

Aim: The purpose of this study was to assess the efficacy of kanamycin (KM) plus metronidazole (MNZ) administration as an oral antibiotic bowel preparation (OABP) for incisional surgical site infection (SSI) in colorectal cancer surgery.<BR>Methods: Three hundred forty-four patients who underwent elective colorectal surgery at our department from April 2010 to March 2015 were enrolled in this retrospective study. The patients were divided into three groups based on their OABP method: without OABP (n = 178), KM only (n = 87), and KM + MNZ (n = 79). We evaluated the incidence of adverse events and analyzed an association between the incidence of incisional SSI and variable factors using univariate and multivariate analyses. Results: Incisional SSI rates in each group were 14.0% (without OABP), 13.8% (KM only), and 1.3% (KM + MNZ). The KM + MNZ group had a significant lower SSI incidence than the other groups (P < 0.05). There was no significant difference in the incidence of adverse events among the groups. Risk factors for SSI were “male” (P = 0.035) and “without KM + MNZ” (P = 0.011).<BR>Conclusions: Administration of KM + MNZ as OABP was effective in preventing incisional SSI in colorectal cancer surgery.

The Efficacy of Kanamycin Plus Metronidazole Administration as an OABP Against Incisional Surgical Site Infection in Colorectal Cancer Surgery

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