- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- 【Updated on June 30, 2025】Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
A case of IgA nephritis showing diffuse podocytic detachment from the glomerular basement membrane.
-
- MORIYA TATSUMI
- Departments of Pathology, Shinshu University School of Medicine
-
- NAKAZAWA KOH
- Departments of Pathology, Shinshu University School of Medicine
-
- ITOH NOBUO
- Departments of Pathology, Shinshu University School of Medicine
-
- SHIGEMATSU HIDEKAZU
- Departments of Pathology, Shinshu University School of Medicine
-
- HIGUCHI MAKOTO
- Internal Medicine (II), Shinshu University School of Medicine
-
- MIYASAKA MAKOTO
- Internal Medicine (II), Shinshu University School of Medicine
-
- OGUCHI HISAO
- Internal Medicine (II), Shinshu University School of Medicine
Search this article
Description
We report the case of a 15-year-old Japanese female with severe mesangial proliferative IgA glomerulonephritis who showed a dramatic response to cocktail therapy for nephrotic syndrome. She had suddenly developed massive proteinuria and microscopic hematuria. The first renal biopsy at one month after onset revealed severe mesangial hypercellularity and podocytic detachment from the glomerular basement membrane (GBM). The cocktail therapy resulted in a decrease of proteinuria clinically, and a second biopsy demonstrated repair of the podocytic detachment. We suggest that the massive proteinuria in this case was due to destruction of the size barrier by detachment of podocytes from the GBM, and the repair of the podocytic covering on the GBM was accelerated by the cocktail therapy.
Journal
-
- The Japanese Journal of Nephrology
-
The Japanese Journal of Nephrology 34 (4), 423-430, 1992
Japanese Society of Nephrology