蛇毒を用いたプロテインＣ活性の測定　　先天性プロテインＣ欠乏症，播種性血管内凝固症候群，血栓性血小板減少性紫斑病，糖尿病，肝障害およびワーファリン服用患者におけるプロテインＣ抗原との比較

DOI オープンアクセス

書誌事項

タイトル別名
  • Measurement of protein C activity using a snake venom: Comparison with an immunoassay in patients with hereditary protein C deficiency, disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, diabetes mellitus, liver injury and during oral anticoagulant therapy.
  • Comparison with an immunoassay in patients with hereditary protein C deficiency, disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, diabetes mellitus, liver injury and during
  • 先天性プロテインC欠乏症, 播種性血管内凝固症候群, 血栓性血小板減少性紫斑病, 糖尿病, 肝障害およびワーファリン服用患者におけるプロテインC抗原との比較検討
公開日
1987
DOI
  • 10.2491/jjsth1970.18.548
公開者
一般社団法人 日本血栓止血学会

この論文をさがす

説明

Functional protein C (PC) activity (both anticoagulant and amidolytic) was measured using a specific PC activator extracted from the venom of Agkistrodon contortrix in 4 patients with hereditary PC deficiency, 37 with disseminated intravascular coagulation (DIC), 9 with thrombotic thrombocytopenic purpura (TTP), 8 with diabetes mellitus (DM), 8 with liver injury and 30 under long-term warfarin therapy. The results were compared with those obtained by an immunological assay (ELISA). In patients with hereditary PC deficiency, DIC and TTP, PC activity was closely related with PC antigen levels. Both functional and immunological PC were decreased in many patients with DIC, while most TTP patients had normal PC levels. Some DM patients had high PC antigen levels, and their PC activity was somewhat lower than the antigen levels. PC activity and antigen were decreased in patients with hepatic injury, but in some of them functional assays (especially anticoagulant assay) gave lower PC values than the immunoassay. During stabilized warfarin treatment, PC antigen and amidolytic activity were decreased in parallel, but a decrease in anticoagulant activity was more pronounced. In addition, only anticoagulant activity correlated significantly with thrombotest values.<br>These results indicate that the measurement of PC activity is valuable for the assessment of the behavior of PC in various disease states. Only anticoagulat PC assay can evaluate the PC function in patients under oral anticoagulant therapy and in some patients with hepatic injury.

収録刊行物

  • 血液と脈管

    血液と脈管 18 (6), 548-556, 1987

    一般社団法人 日本血栓止血学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390282679836645248
  • NII論文ID
    130004261272
  • DOI
    10.2491/jjsth1970.18.548
  • ISSN
    18842372
    03869717
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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