The effect of elastase on Masugi nephritis of rats.

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Bibliographic Information

Other Title
  • エラスターゼのラット馬杉腎炎に対する影響

Abstract

Elastase has been known as having elastin lytic action and also as a drug having control action of hyperlipidemia and atherosclerosis. To investigate the action of Elastase on Masugi nephritis, 5 mg (group E5) or 1 mg (group E1) of Elastase and PBS (group E0) as a control were ip injected every day for eight weeks. The rats were unilatelally nephrectomized at 4th week and sacrificed at 8th week. The amount of proteinuria was E0>E1≅E5. Severity of fibrin deposits in glomeruli was E0>E1>E5. Severity of the renal histology was quantitatively evaluated using the enlarged photographs by computerized surface measurement and were E0>E1>E5 in glome-rular sclerosis, cresent and cellular infiltration of tubulo-interstitial tissue. The widening of glomerular tuft and Bowman's capsule were E0≅E1≅E5. These data suggested that Elastase had protective action in the progression of Masugi nephritis and might be useful for human kidney diseases.

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Details 詳細情報について

  • CRID
    1390282679836749440
  • NII Article ID
    130004169448
  • DOI
    10.14842/jpnjnephrol1959.30.1333
  • ISSN
    18840728
    03852385
  • PubMed
    3236515
  • Text Lang
    ja
  • Data Source
    • JaLC
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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