Effects of three platelet aggregation inhibiting drugs on thrombos formation induced by Argon-gas laser in rat aortas

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  • レーザーによる血栓形成ならびに内皮細胞障害に対する抗血小板凝集剤の影響について

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Description

Inhibitory effects of three drugs (Gliclazid, Phthalazinol and 1-methyl-2-mercapto-5-(3-pyridyl)-imidazole) on thrombus formation in rat aortas induced by Argon-gas laser were investigated histologically and ultrastructually. All three drugs showed more or less inhibitory effects on thrombus formation. Ultrastructually 1-methyl-2-mercapto-5-(3-pyridyl)-imidazole and Gliclazid showed a tendency to inhibit the adhesion and aggregation of platelets against coagulated plasma constitutents by laser heat and on the exposed subendothelial constitutents.

Journal

  • Blood & Vessel

    Blood & Vessel 11 (3), 403-406, 1980

    The Japanese Society on Thrombosis and Hemostasis

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