Syndrome of inappropriate ADH secretion (SIADH) induced by pramipexole in a patient with Parkinson's disease
-
- TOMITA Masuomi
- Division of Nephrology, Saiseikai Central Hospital
-
- HOSOYA Tatsuo
- Department of Kidney & Hypertension, Jikei University School of Medicine
Bibliographic Information
- Other Title
-
- 抗パーキンソン病薬プラミペキソール(ビ・シフロール)投与によりADH不適切分泌症候群(SIADH)を発症した1例
- ショウレイ コウパーキンソンビョウヤク プラミペキソール ビ シフロール トウヨ ニ ヨリ ADH フテキセツ ブンピ ショウコウグン SIADH オ ハッショウ シタ 1レイ
Search this article
Abstract
An 85-year-old woman with Parkinson's disease was admitted to our hospital to conduct a further work-up for progressive gait disturbance. She had been on medications for the disease for more than a decade prior to admission. In order to improve her condition, she was newly administered pramipexole, a dopamine agonist, from day 3 in addition to the preceding anti-Parkinson's therapy. However, on day 10, her consciousness level was rapidly deteriorated into delirium (JCS II-10), which was not accompanied by neurological signs and symptoms. Laboratory tests showed severe hyponatoremia with relatively increased urinary sodium excretion, and severe low serum osmolarity with an increased urinary osmolarity. Brain CT and brain MRI showed no specific abnormalities except for those related to aging. Blood concentration of ADH measured at the onset was substantially higher (39.5pg/ml) than normal (0.3-3.5pg/ml under normal osmolarity). Diseases causing hyponatremia, such as liver cirrhosis, congestive heart failure, hypotonic dehydration, and malignancy-associated inappropriate ADH secretion (SIADH), were all excluded. Under the suspicion of SIADH due to pramipexole, the drug was discontinued and as a result, her consciousness level improved rapidly together with a prompt reduction in ADH level (9.2pg/ml).<br>To the best of our knowledge, the present case is the first that demonstrates pramipexole-induced SIADH. Since pramipexole is classified as a dopaminergic receptor agonist, this case may provide new insight into a link between ADH and the dopaminergic receptor in the central nervous system.
Journal
-
- The Japanese Journal of Nephrology
-
The Japanese Journal of Nephrology 47 (5), 531-535, 2005
Japanese Society of Nephrology
- Tweet
Details 詳細情報について
-
- CRID
- 1390282679837615232
-
- NII Article ID
- 40006892767
- 130004170723
-
- NII Book ID
- AN10131749
-
- ISSN
- 18840728
- 03852385
-
- NDL BIB ID
- 7466296
-
- PubMed
- 16130408
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed