A Study of the influence of Prognancy on Heymann Nephritis

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  • Heymann腎炎における妊娠の影響
  • Heymann ジンエン ニ オケル ニンシン ノ エイキョウ

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Abstract

The purpose of this paper is that in order to determine, how pregnancy influence on nephritis rats (Heymann nephritis (HN )). HN was developed by multiple injections of isologous kidney suspension emulsified in Complete Freundt's Adjuvant in combination with pertussis vaccine. The experimental anima. 1. were deviled into 3 groups, i.e.group 1, pregnant rats with HN (n=16), group 2 nonpregnant rats with RN (n=9) and group 3 pregnant rats without HN (n=12). Using these animals, clinicopathological studies were performed. The amount of urine protein and urine FDP increased in all rats with RN by 7th weeks, but after the gestation, the amount of urine protein of rats in group 1 increased significantly (205.6±51.9 mg/day), compared to the rats in group 2 (136.3±59.6 mg/day). The decreased serum total protein was also observed in group 1. By lightmicroscopy (PTAH staining) and immunofluorescence, fibrin/fibrinogen were frequently observed in the mesangial area and in the lumen of cappillary loops in group 1. Birth rate decreased significantly in group 1 (6.3±4.2/rat), compared with group 3 (12.2±2.8/rat). The renal specimen obtained from Fl hybrid from the pregn ant rats with HN and the placenta revealed no abnormality in lightmicroscopy and no deposit of rat IgG and C3. These findings suggested that the events of "pregnancy" stimulate coagulation systems and exagga erated glomerular changes.

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