AN ELECTRON MICROSCOPICAL STUDY OF THE ADRENAL MEDULLA IN SPONTANEOUSLY HYPERTENSIVE RATS, PARTICULARLY ON CATECHOLAMINE-GRANULES IN SECRETING CELLS

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Recently it has been stressed that catecholamines play a significant role in the pathogenesis of hypertension in Spontaneously Hypertensive Rats (Okamoto and Aoki) (SHR). In this report electron microscopical observation in male SHR was made on the adrenal medulla through the processes of the hypertension. The mild hyperfunctional state of norepinephrine-secreting cells in the initial stage of hypertension was expected on the feature of increased population of norepinephrine-secreting cells, its prominent Golgi complex and rough-surfaced endoplasmic reticulum and increased degranulation in the cell. Moreover, it may be assumed a certain functional change of epinephrine-secreting cell system on the base of increased population of dark epinephrine-secreting cells which are regarded as premature cells.

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