腎疾患における尿kallikreinについて

DOI Web Site PubMed
  • 沼畑 博雄
    弘前大学医学部第二内科 黎明郷リハビリテーション病院 鷹揚郷腎研究所

書誌事項

タイトル別名
  • A Clinical Study on Urinary Kallkrein in Patients with Renal Diseases
  • ジン シッカン ニ オケル ニョウ kallikrein ニ ツイテ

この論文をさがす

説明

The activity of urinary kallikrein was measured by using tosyl-arginine methyl ester as a substrate and was expressed as an esterase activity. The examinees were 25 normal persons and 94 patients consisting of 56 cases with nephrotic syndrome (19 in the acute atage, 37 in the latent stage), 17 cases with chronic glomerulonephritis and 21 with chronic renal failure (9 with and 12 without hemodialysis). The results obtained are as follows : 1) This method modified by the author is suitable for estimating kallikrein activity in human urine. 2) The urine esterase activity estimated according to the author's method can be regarded as the urine kallikrein activity, as the esterase activity can not be detected by the author's method in the standard solutions of urokinase which is contained in human urine and has an esterase activity smiilar to the urine kallikrein. 3) The daily urinary kallikrein excretion (KE) is less in chronic glomerulonephritis and outstandingly less in chronic renal failure than in the normal controls. 4) KE shows a close positive correlation to 15.min PSP excretion, and a faint one to creatinine clearance, that is KE shows a positive correlation to renal functon. 5) The KE of six cases with various renal diseases were observed, continuously from the acute stage to the convalescent stage. No definite tendency was found in the course of KE. 6) There is no relation between the kallikrein activity and the concentration of urine protein, even though observed by 15-min PSP in 3 excretion groups. 7) The kallikrein activity is parallel, in general, to the urokinase activity. 8) In nephrotic syndrome, the kallikrein activity is apt to show a negative correlation to the urine α1-antitrypsin ; α1-antitrypsin being an inhibitor to blood kallikrein. It is suggested that the urine α1-antitrypsin can function as an inhibitor to the urine kallikrein. (Autoabstract)

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ