Plasma Catecholamine Concentration and Plasma Dopamine-beta-Hydroxylase Activity in Patients Undergoing Chronic Hemodialysis

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  • Sakuma Hisaichi
    The Second Deportment of Interncl Medicine, Tohoku University School of Medicine
  • Miura Yukio
    The Second Deportment of Interncl Medicine, Tohoku University School of Medicine
  • Kobayashi Kiyoshi
    The Second Deportment of Interncl Medicine, Tohoku University School of Medicine
  • Tomioka Hiroshi
    The Second Deportment of Interncl Medicine, Tohoku University School of Medicine
  • Adachi Maki
    The Second Deportment of Interncl Medicine, Tohoku University School of Medicine
  • Furuyama Takashi
    The Second Deportment of Interncl Medicine, Tohoku University School of Medicine
  • Yoshinaga Kaoru
    The Second Deportment of Interncl Medicine, Tohoku University School of Medicine
  • Sekino Hiroshi
    Kidney Center, SendLi SocUl Insurercance Hospittal, Sendci, Jcpcn
  • Ishizaki Tsutomu
    Kidney Center, SendLi SocUl Insurercance Hospittal, Sendci, Jcpcn

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Other Title
  • 血液透析患者における血漿カテコラミン濃度および血漿ドーパミン-β-水酸化酵素活性について
  • ケツエキ トウセキ カンジャ ニ オケル ケッショウ カテコラミン ノウド オ

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Plasma catecholamine concentration and plasma dopamine-beta-hydroxylase (DBH) activity were studied in 22 subjects undergoing choronic hemodialysis. Significantly raised plasma norepinephrine (NE) concentration and reduced plasma DBH activity were observed in these subjects resting supine for 1 hour prior to hemodialysis. During the hemodialysis, plasma NE concentration was increased remarkably and returned promptly to pre-dialysis values after stopping the dialysis, whereas plasma epinephrine concentration was increased gradually through the late and post-dialysis period. Plasma DBH activities showed a gradual increase along with the lapse of dialysis. But, these variations were not statistically significant, when the values were tested with correcting its relative changes by those of total protein concentration in the plasma. The variations of plasma NE concentrations during hemodialysis correlated negatively with those of mean arterial pressures or positively with those of heart rates, plasma protein concentrations and hematocrits, respectively. Severe hypoten-sive episodes during dialysis were associated with a comparable rise in plasma NE to those in other normptensive and hypertensive patients. Plasma catecholamine concentration appears to be a more sensitive marker of sympathetic nervous activity in dialyzed patients than plasma DBH activity, although both indices might be influenced not only by sympathetic nervous activity, but also by several foctors related directly to the condition of renal failure. Remarkable changes of plasma NE concentrations during the hemodialysis indicate that sympathetic nervous system is of primary im-portance to maintain the blood circulation against the rapid depletion of extracellular fluid volume induced by this procedure.

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