The Study on hypertension: The renin-angiotensin system in the adrenalectomized dog

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  • YAMAJI TAATSUGU
    Dept. of Intern. Med. (Direct. Prof. K. OSHI MA) Nihon Univ. Sch. of Med.

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  • 高血圧に関する研究　副腎摘出犬のrenin-angiotensinについて
  • コウケツアツ ニ カンスル ケンキュウ フクジン テキシュツケン ノ renin-angiotensin ニ ツイテ

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In this study I have investigated the role of plasma renin activity in blood pressure regulation of pthe experimental renal hypertensive dog (Goldblatt' type). Removal r of the adrenals was followed, by lowering of blood pressure approximately 25%, and then plasma renin activity (by the method of Page et al) increased. In experimental renal hypertensive dogs subjected to complete adrenalectomy, it could be observed that arterial blood pressure did not increase in spite of the high renin concentration. Cortisone 100 mg/dog/day` administration to such animals for 7 days rose blood pressure over normal level, whilee plasma, renin activity was not different from that of the non-administered. In 2 dogs the accessory adrenals .were found, , high renin activity and hypertension were observed. It is apparent, therefore, that arterial blood pressure has no correlation to plasma renin concentration. Adrenalectomy reduced serum sodium content and increased potassium. But in 2 dogs with cortisone administration, these ions restored to normal levels. GFR and RPF were decreased approximately 20% with adrenalectomy and 50% with adrenalectomized Goldblatt' dog. These were not influenced with cortisone administration. The intravenous' injection of synthetic angiotensin-II (Hypertensin Ciba) 0, 5 γ into such animals did not produce a significant decrease of the pressor response. There were no correlation between pressor response and plasma renin activity or serum sodium content. Blood catecholamines were hot influenced significantly in all experimental stages. These results were discussed, it is suggested that increased plasma, a renin activity and secretion of aldosterone or glucocorticoids from the adrenal cortex may be an essential factors in the developement of the experimental renal hypertension.

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