運動負荷による血漿レニン活性の変動に関する研究

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  • 石丸 勝雄
    徳島大学医学部第二内科学教室 徳島大学医学部附属病院中央臨床検査部

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  • Studies on effect of exercise on plasma renin activity
  • ウンドウ フカ ニヨル ケッショウ レニン カッセイ ノ ヘンドウ ニカンスル

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Changes of plasma renin activity (PRA), blood pressure and heart rate were observed for 2 hours of physical exercise loaded on normal subjects. The PRA was significantly decreased in comparison with the basal value both 1 and 3 minutes after the initiation of the exercise, but returned to the basal value 5 minutes after the initiation of the exercise followed by a significant elevation from 30 minutes to the end of the exercise. The mean blood pressure was elevated significantly 1 minute after the initiation of the exercise and remained elevated throughout the period of exercise. <BR>In order to clarify causes of the above-mentioned transient decrease in PRA observed immediately after the initiation of the exercise, the same experiment was performed in patients with hyperthyroidism, who were considered to be sympaticotonic, with or without the pretreatment of propranolol. The PRA in the patients with hyperthyroidism remained unchanged for initial 1 minute after the onset of the exercise, but a rapid elevation observed 3 minutes after the initiation of the exercise lasted throughout the experiment. Little alterations were observed both 1 and 3 minutes after the initiation of the exercise in the patients with hyperthyroidism pretreated by propranoloh. <BR>The PRA of the renal venous blood (RPRA) in dogs whose blood pressure in renal arteries was lowered by constricting the abdominal aorta just above the branching portion of the renal arteries showed 3-fold increase compared to the control value. The RPRA was decreased transi-ently at 30 seconds, then increased slightly one minute after the release of the constriction, and returned gradually to the control value afterwards. These results may suggest that a transient decrease in PRA immediately after the initiation of the exercise in normal subjects is resulted from the sympathicGtonia that has been brougnt about just after the exercise, and is related to the concomitant rapid elevation of blood pressure.

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