Significance of urine dipstick test for occult blood in patients with diabetes mellitus

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  • OHISA Noriko
    Department of Clinical Laboratory, Tohoku University Hospital
  • YOSHIDA Katsumi
    Department of Medical Technology, Tohoku University of Health Sciences
  • KAKU Mitsuo
    Department of Infection Control and Diagnostics, Internal Medicine, Tohoku University Graduate School of Medicine
  • ISHIGAKI Yasushi
    Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine
  • OKA Yoshitomo
  • SATO Hiroshi
    Division of Nephrology, Endocrinology, and Hypertension, Tohoku University Hospital

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Other Title
  • 糖尿病患者における尿潜血反応陽性の意義
  • トウニョウビョウ カンジャ ニ オケル ニョウセンケツ ハンノウ ヨウセイ ノ イギ

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Objective: Hematuria is the usual urinary finding in patients with diabetic nephropathy. In this study, prevalence and significance of microhematuria in patients with diabetes mellitus were investigated.<br>Material and methods: Five hundred and forty-two samples from outpatients, who consulted the Department of Diabetes and Metabolism, were categorized into 4 groups according to the results of the urine dipstick test. Group I: 258 samples, urinary protein (u-P) 1+ and occult blood (OB) negative, group II: 95 samples: u-P 1+, OB1+-3+, group III: 89 samples: u-P 2+-3+, OB negative, group IV 100 samples u-P 2+-3+, OB 1+-3+.<br>Results: Serum concentrations of creatinine and highly sensitive CRP were both significantly higher in group II than in group I. Those parameters were also significantly higher in group IV than in group III.<br>Conclusions: These results indicate that a positive dipstick test for OB may occur in many patients with diabetes mellitus and suggest the progress of renal damage.

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