Activation of the Non-receptor Tyrosine Kinase cSrc in Macrophage-rich Atherosclerotic Plaques of Human Carotid Arteries
-
- Toi Sono
- Department of Neurology, Tokyo Women’s Medical University
-
- Shibata Noriyuki
- Department of Pathology, Tokyo Women’s Medical University
-
- Sawada Tatsuo
- Department of Pathology, Tokyo Women’s Medical University
-
- Kobayashi Makio
- Department of Pathology, Tokyo Women’s Medical University
-
- Uchiyama Shinichiro
- Department of Neurology, Tokyo Women’s Medical University
この論文をさがす
説明
To determine the involvement of the non-receptor tyrosine kinase cSrc in plaque destabilization in carotid atherosclerosis (CAS), which is responsible for cerebral infarction, we performed quantitative and morphological detection of phosphorylated active cSrc (p-cSrc) and histopathological examination in CAS lesions. We examined carotid endarterectomy specimens obtained from 32 CAS patients. Each specimen was used for immunoblot and immunohistochemical analyses of p-cSrc, histopathological analysis, and image analysis of macrophage content. There was a strong positive correlation between cSrc activation on blots and macrophage content on sections. When we defined the macrophage-rich plaque (MRP) and the macrophage-poor plaque (MPP) as having macrophage content more and less than 5%, respectively, the p-cSrc density and the occurrence of plaque hemorrhage and thrombus formation were significantly increased in the MRP group (n=18) compared to the MPP group (n=14). p-cSrc immunoreactivity was localized in lesional endothelial cells, macrophages, and smooth muscle cells, which contained proinflammatory substances: the upstream oxidized low density lipoprotein, tissue factor and osteopontin, and the downstream active forms of extracellular signal-activated kinase and p38 and nuclear factor-κB. Our results suggest that cSrc activation in lesional cells contributes to plaque destabilization in CAS via persistent inflammation.<br>
収録刊行物
-
- Acta Histochemica et Cytochemica
-
Acta Histochemica et Cytochemica 40 (6), 153-161, 2007
日本組織細胞化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679839728640
-
- NII論文ID
- 110006633426
-
- NII書誌ID
- AA00508022
-
- ISSN
- 13475800
- 00445991
-
- PubMed
- 18224247
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- NDLデジコレ(旧NII-ELS)
- CiNii Articles
- OpenAIRE
-
- 抄録ライセンスフラグ
- 使用不可