Localization of energy metabolism-related oxidoreductases in the testis.

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It is well known that mammalian spermatozoa utilize fructose as an energy source, and glycerol can also be metabolized for this purpose. Further, oxidoreductases related to energy metabolism, such as sorbitol dehydrogenase and α-glycerophosphate dehydrogenase, are contained in the testis. These enzymes contribute fructose synthesis and glycerol metabolism, respectively.<br>In this paper, the precise localization of these energy metabolism-related oxidoreductases was studied by electron microscopy. The results indicated that sorbitol dehydrogenase located in the cytoplasm of Sertoli cells adjacent to the late stage spermatids. On the other hand, α-glycerophosphate dehydrogenase was recognized in the mitochondria of late stage spermatids and spermatozoa. Therefore, fructose is presumably synthesized in the cytoplasm of the Sertoli cells, and glycerol is metabolized at the mitochondria of the sperm.

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