Lymphocytic interstitial pneumonia associated with a marked increase in monoclonal IgM-.KAPPA.-type rheumatoid factor and serum CA19-9.

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  • TAKATA Tohru
    The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • NAGAFUCHI Seiho
    The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • TSUDA Hiroko
    The First Department of Clinical Laboratory, Faculty of Medicine, Kyushu University
  • UEHIRA Kenji
    The Second Department of Pathology, Faculty of Medicine, Kyushu University
  • KONDO Seiji
    The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • UEDA kira
    The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • ISHII Hiroshi
    The First Department of Pathology, Faculty of Medicine, Kyushu University
  • NIHO Yoshiyuki
    The First Department of Internal Medicine, Faculty of Medicine, Kyushu University

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Description

A 62-year-old Japanese female was admitted due to dyspnea. She showed a marked increase in CA19-9 (maximum, 192, 000 U/ml) and monoclonal IgM- κ type rheumatoid factor (RF) activity. The patient died of respiratory failure 3 months later. Autopsy findings revealed an infiltration of IgM- κ -positive plasma cells in the pulmonary interstitium, and therefore a diagnosis of lymphoid interstitial pneumonia (LIP) was made. The bronchoepithelial cells were stained with monoclonal antibody-reactive with CA19-9 antigen. This is the first documented LIP, associated with a marked increase in monoclonal IgM- κ type RF and CA19-9 in the serum.

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