A Diabetic Case of Hb Riyadh with a Low HbA1c Value.

  • MAEZAWA Yoshihiko
    the First Department of Internal Medicine, the Jikei University School of Medicine
  • YAMAUCHI Masayoshi
    the First Department of Internal Medicine, the Jikei University School of Medicine
  • NAKABAYASHI Tomoko
    the First Department of Internal Medicine, the Jikei University School of Medicine
  • TOSHIMA Kyouichirou
    the First Department of Internal Medicine, the Jikei University School of Medicine
  • IKEDA Kiyoko
    the Division of Clinical Laboratory, the Jikei University School of Medicine
  • TODA Gotaro
    the First Department of Internal Medicine, the Jikei University School of Medicine

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説明

A 74-year-old male patient with diabetes mellitus and hypertension who had been treated for a long period was admitted to our hospital. Laboratory data on admission revealed high values for fasting blood sugar and fructosamine, 219 mg/dl and 389 μmol/l respectively, while the concentration of glycated hemoglobin (HbA1c) was low (3.0%). High performance liquid chromatography and isoelectric focusing analysis of the patient's Hb disclosed abnormal Hb with the content being 41.3%. The structural analysis indicated that this abnormal Hb was Hb Riyadh [β120 (GH3) Lys→Asn]. The low value of HbA1c despite the high blood glucose level may be attributed to this abnormal hemoglobin.<br>(Internal Medicine 32: 128-132, 1993)

収録刊行物

  • Internal Medicine

    Internal Medicine 32 (2), 128-132, 1993

    一般社団法人 日本内科学会

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