Membranoproliferative Glomerulonephritis and Leukocytoclastic Vasculitis without Cryoglobulin in Chronic Hepatitis C Virus Infection
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- NAKAJIMA Ayako
- The Division of Rheumatology, Tokyo Metropolitan Ohtsuka Hospital
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- ADACHI Masayuki
- The Division of Rheumatology, Tokyo Metropolitan Ohtsuka Hospital
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- TANAKA Michi
- The Division of Rheumatology, Tokyo Metropolitan Ohtsuka Hospital
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- SUWA Akira
- The Division of Rheumatology, Tokyo Metropolitan Ohtsuka Hospital
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- YASUKI Yoshihiro
- Division of Dermatology, Tokyo Metropolitan Ohtsuka Hospital
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- IMAEDA Hiroyuki
- Division of Internal Medicine, Tokyo Metropolitan Ohtsuka Hospital
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- INADA Shinichi
- The Division of Rheumatology, Tokyo Metropolitan Ohtsuka Hospital
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The etiopathogenesis of extrahepatic manifestations including vasculitis in the context of HCV infection is still unknown. We report a case with lethal extrahepatic manifestations due to chronic hepatitis C virus (HCV) infection. The patient presented leukocytoclastic vasculitis, sensorimotor neuropathy and membranoproliferative glomerulonephritis with positive rheumatoid factor but lacked cryoglobulin. Hypocomplementaemia and deposition of IgM and C3 in the vascular lesion and glomeruli suggested that immune complex disease played a role in the pathogenesis of extrahepatic manifestations independent of cryoglobulin. Although HCV was successfully eliminated by treatment with interferon α, she died of cryptococcal infection.<br>(Internal Medicine 42: 1042-1046, 2003)
収録刊行物
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- Internal Medicine
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Internal Medicine 42 (10), 1042-1046, 2003
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679843177600
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- NII論文ID
- 10012457427
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- NII書誌ID
- AA10827774
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- COI
- 1:STN:280:DC%2BD3srivVKrsw%3D%3D
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- ISSN
- 13497235
- 09182918
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- NDL書誌ID
- 6721713
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- PubMed
- 14606724
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可