Emergence of Acute Interstitial Pneumonia Following High Dose Interferon .PDRV. Treatment in a Case of Chronic Myelogenous Leukemia.

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  • MURATA Michio
    the First Department of Internal Medicine, Kagawa Medical School
  • NAGAI Masami
    the First Department of Internal Medicine, Kagawa Medical School
  • BANDO Syuji
    the First Department of Internal Medicine, Kagawa Medical School
  • DOBASHI Hiroaki
    the First Department of Internal Medicine, Kagawa Medical School
  • TAKAHARA Jiro
    the First Department of Internal Medicine, Kagawa Medical School

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Here we report a 58-year-old man with chronic myelogenous leukemia in the chronic phase, who developed acute respiratory failure following administration of high dose natural interferon σ (6, 300×l04 units/week). Radiological and histological findings were consistent with acute interstitial pneumonia (AIP). Although the pathogenesis remains unclear, it is important to watch for the possible development of AIP when employing interferon σ therapy, especially at high doses.<br>(Internal Medicine 32: 716-718, 1993)

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  • Internal Medicine

    Internal Medicine 32 (9), 716-718, 1993

    The Japanese Society of Internal Medicine

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