Motor Neuron Involvement in a Patient with Long-term Corticosteroid Administration

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  • MTSUI Takao
    The First Department of Internal Medicine, School of Medicine, The University of Tokushima
  • UMAKI Yoshifumi
    The First Department of Internal Medicine, School of Medicine, The University of Tokushima
  • NAGASAWA Masakazu
    Analytical Department, Formulation Research Institute, Otsuka Pharmaceutical Co., Ltd.
  • AKAIKE Masashi
    The First Department of Internal Medicine, School of Medicine, The University of Tokushima
  • OHTSUKA Satoshi
    The First Department of Internal Medicine, School of Medicine, The University of Tokushima
  • ODOMI Masaaki
    Analytical Department, Formulation Research Institute, Otsuka Pharmaceutical Co., Ltd.
  • AKI Kenji
    Institute for Enzyme Research, The University of Tokushima
  • MATSUMOTO Toshio
    The First Department of Internal Medicine, School of Medicine, The University of Tokushima

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Description

An asthmatic patient with corticosteroid treatment for 45 years presented with slowly progressive limb muscle atrophy. His muscle symptoms were involved in four limbs and tongue, and deep tendon reflexes were exaggerated. Biopsied muscle pathology indicated the presence of neurogenic muscular atrophy in combination with corticosteroid myopathy. Furthermore, 8-hydroxy-deoxyguanosine (8-OH-dG) was prominently increased in mitochondrial and nuclear DNA. An aerobic exercise test demonstrated remarkable serum lactate elevation, which was attenuated by the administration of coenzyme Q10- These findings are consistent with the assumption that long-term corticosteroid administration potentially induces not only myopathy but also motor neuron involvement as in mitochondrial diseases.<br>(Internal Medicine 42: 862-866, 2003)

Journal

  • Internal Medicine

    Internal Medicine 42 (9), 862-866, 2003

    The Japanese Society of Internal Medicine

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