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Anaphylaxis to Aprotinin in Fibrin Sealant
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- SHIRAI Toshihiro
- Departments of Internal Medicine and Surgery, Fujinomiya City General Hospital
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- SHIMOTA Hiroshi
- Departments of Internal Medicine and Surgery, Fujinomiya City General Hospital
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- CHIDA Kingo
- Second Department of Internal Medicine, Hamamatsu University School of Medicine
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- SANO Shinichi
- Kyoai Clinic, Fujinomiya
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- TAKEUCHI Yasuo
- Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
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- YASUEDA Hiroshi
- Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
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Description
A 50-year-old man with chronic otitis media was admitted to our hospital for investigation of lung cancer. He had received repeated instillations of fibrin sealant (Bolheal) in myringoplasty 7 times over 12 months. During the lower lobectomy, soon after fibrin sealant was applied to seal bronchopleural fistulas, systolic blood pressure decreased to 60 mmHg. Treatment with epinephrine and dopamine was required until his condition improved 2 days later. The specific IgE antibody was detected for the solution for fibrinogen and factor XIII containing bovine aprotinin. Cross-reactivity between purified aprotinin and the solution was noted by competitive ELISA inhibition tests.
Journal
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- Internal Medicine
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Internal Medicine 44 (10), 1088-1089, 2005
The Japanese Society of Internal Medicine
